Prognostic Value of Cardiac Troponin T, Cardiac Troponin I and CK-MB among Chronic Renal Failure
- Al-Ghad International College for Applied Medical Sciences, Kingdom of Saudi Arabia
- aculty of Medical Laboratory Science, Department of microbiology, Nile University, Khartoum, Sudan
- Faculty of Medical Laboratory Science, Department of clinical chemistry, Alneelain University, Khartoum, Sudan
- Ahfad University for Women, Sudan
Abstract
Background: Cardiac troponin T (cTnT) is a highly sensitive and specific marker of myocardial damage. The aim of this study was to investigate the prognostic value of a new sensitive TnT assay in comparison with TnI and other cardiac markers. Methods: We measured serial pre- and post-dialysis cTnT, cTnI, and creatine kinase-MB (CK-MB) concentrations in 100 patients with end-stage renal failure without signs of acute myocardial infarction. Sera were analyzed for cardiac troponin T (cTnT) using the Elecsys Analyzer 2010 immunoassay system and for cardiac troponin I (cTnI) using the Immulite automated immunoassay analyzer. Results: There were no significant differences in pre- and post-dialysis values for TnT and TnI (p ≥ 0.05), while CK and CK-MB levels were significantly lower post-dialysis (p ≤ 0.05). Elevated pre-dialysis levels above the upper reference limits were found in 35 patients (35%) with the TnI assay (p ≥ 0.05) and in 65 patients (65%) with the TnT assay (p ≤ 0.05). Conclusions: Elevated troponin T identifies a subgroup of ESRD patients who may be at increased risk of cardiac infarction, even among asymptomatic individuals.